Uncovering Novel Cell Cycle Players Through the Inactivation of Securin in Budding Yeast | Zendy

Sumeet Sarin | Zendy; Karen Ross | Zendy; Lorrie Boucher | Zendy; Yvette Green | Zendy; Mike Tyers | Zendy; Orna CohenFix | Zendy

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Uncovering Novel Cell Cycle Players Through the Inactivation of Securin in Budding Yeast

Author(s) -

Sumeet Sarin,

Karen Ross,

Lorrie Boucher,

Yvette Green,

Mike Tyers,

Orna CohenFix

Publication year - 2004

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.104.029033

Subject(s) - securin , separase , biology , anaphase , budding yeast , anaphase promoting complex , microbiology and biotechnology , cell cycle , genetics , mitosis , cell cycle checkpoint , cdc20 , gene , activator (genetics) , saccharomyces cerevisiae

Budding yeast securin/Pds1p, an inhibitor of the anaphase activator separase/Esp1p, is involved in several checkpoint pathways and in promoting Esp1p's nuclear localization. Using a modified synthetic genetic array (SGA) screen for genes that become essential in the absence of Pds1p, we uncovered roles for uncharacterized genes in cell cycle processes, including Esp1p activation.

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