Open AccessA Novel Solution for the Time-Dependent Probability of Gene Fixation or Loss Under Natural Selection
Author(s) -
Ying Wang,
Bruce Rannala
Publication year - 2004
Publication title -
genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.792
H-Index - 246
eISSN - 1943-2631
pISSN - 0016-6731
DOI - 10.1534/genetics.104.027797
Subject(s) - biology , natural selection , genetics , selection (genetic algorithm) , fixation (population genetics) , gene , computational biology , computer science , artificial intelligence
Kimura proposed a solution for the time-dependent probability of fixation, or loss, of a gene under selection. Example calculations suggest the formulas are prone to numerical inaccuracies. An alternative solution is proposed; the correctness of the solution is confirmed by numerically solving the Kolmogorov backward equation and by simulation.
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