Open AccessIncreased Glyoxalase-1 Levels in Fkbp5 Knockout Mice Caused by Glyoxalase-1 Gene Duplication
Author(s) -
Lorenz Korbinian Kollmannsberger,
Nils C. Gassen,
Andrea Bultmann,
Jakob Hartmann,
Peter Weber,
Mathias V. Schmidt,
Theo Rein
Publication year - 2013
Publication title -
g3 genes genomes genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.468
H-Index - 66
ISSN - 2160-1836
DOI - 10.1534/g3.113.006445
Subject(s) - fkbp5 , knockout mouse , gene duplication , conditional gene knockout , gene knockout , gene , biology , genetics , phenotype , glucocorticoid receptor
Fkbp5 is genetically linked to stress-related diseases. Fkbp5 knockout mice are available and widely used to explore the role of Fkbp5 in health and disease. We found that these mice carry a gene duplication of glyoxylase-1, which explains why glyoxylase-1 levels are increased in the Fkbp5 knockout mice.
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