PUF-8, a Pumilio Homolog, Inhibits the Proliferative Fate in theCaenorhabditis elegansGermline | Zendy

Hilary Racher | Zendy; Dave Hansen | Zendy

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PUF-8, a Pumilio Homolog, Inhibits the Proliferative Fate in theCaenorhabditis elegansGermline

Author(s) -

Hilary Racher,

Dave Hansen

Publication year - 2012

Publication title -

g3 genes genomes genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.468

H-Index - 66

ISSN - 2160-1836

DOI - 10.1534/g3.112.003350

Subject(s) - caenorhabditis elegans , germline , biology , microbiology and biotechnology , mutant , cell fate determination , stem cell , notch signaling pathway , regulator , genetics , signal transduction , gene , transcription factor

Stem cell populations are maintained by keeping a balance between self-renewal (proliferation) and differentiation of dividing stem cells. Within the Caenorhabditis elegans germline, the key regulator maintaining this balance is the canonical Notch signaling pathway, with GLP-1/Notch activity promoting the proliferative fate. We identified the Pumilio homolog, PUF-8, as an inhibitor of the proliferative fate of stem cells in the C. elegans germline. puf-8(0) strongly enhances overproliferation of glp-1(gf) mutants and partially suppresses underproliferation of a weak glp-1(lf) mutant. The germline tumor that is formed in a puf-8(0); glp-1(gf) double mutant is due to a failure of germ cells to enter meiotic prophase. puf-8 likely inhibits the proliferative fate through negatively regulating GLP-1/Notch signaling or by functioning parallel to it.

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