Application of Divide and Conquer Extended Genetic Algorithm to tertiary protein structure of chymotrypsin inhibitor-2 | Zendy

Alexandre da Trindade Alfaro | Zendy; Minh Tuan Doan | Zendy; John M. Finke | Zendy; M. Galdes | Zendy; Mohammed Zohdy | Zendy

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Application of Divide and Conquer Extended Genetic Algorithm to tertiary protein structure of chymotrypsin inhibitor-2

Author(s) -

Alexandre da Trindade Alfaro,

Minh Tuan Doan,

John M. Finke,

M. Galdes,

Mohammed Zohdy

Publication year - 2006

Publication title -

applied bionics and biomechanics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.397

H-Index - 23

eISSN - 1754-2103

pISSN - 1176-2322

DOI - 10.1533/abbi.2006.0038

Subject(s) - divide and conquer algorithms , protein tertiary structure , chymotrypsin , amyotrophic lateral sclerosis , computational biology , computer science , dimension (graph theory) , algorithm , theoretical computer science , computational chemistry , artificial intelligence , chemistry , bioinformatics , biology , mathematics , biochemistry , combinatorics , disease , enzyme , medicine , trypsin , pathology

Determining the method by which a protein thermodynamically folds and unfolds in three-dimension is one of the most complex and least understood problems in modern biochemistry. Misfolded proteins have been recently linked to diseases including Amyotrophic Lateral Sclerosis and Alzheimer's disease. Because of the large number of parameters involved in defining the tertiary structure of proteins, based on free energy global minimisation, we have developed a new Divide and Conquer (DAC) Extended Genetic Algorithm. The approach was applied to explore and verify the energy landscape of protein chymotrypsin inhibitor-2

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