Circulating 1,3-Beta-D-Glucan is Associated with Lung Function, Respiratory Symptoms, and Mediators of Matrix Degradation in Chronic Obstructive Pulmonary Disease | Zendy

Matthew Gorgone | Zendy; Deepti Singhvi | Zendy; Mehdi Nouraie | Zendy; Malcolm Finkelman | Zendy; Yonglong Zhang | Zendy; Jiantao Pu | Zendy; Divay Chandra | Zendy; Yingze Zhang | Zendy; Georgios D. Kitsios | Zendy; Alison Morris | Zendy; Frank C. Sciurba | Zendy; Jessica Bon | Zendy

Open Access

Circulating 1,3-Beta-D-Glucan is Associated with Lung Function, Respiratory Symptoms, and Mediators of Matrix Degradation in Chronic Obstructive Pulmonary Disease

Author(s) -

Matthew Gorgone,

Deepti Singhvi,

Mehdi Nouraie,

Malcolm Finkelman,

Yonglong Zhang,

Jiantao Pu,

Divay Chandra,

Yingze Zhang,

Georgios D. Kitsios,

Alison Morris,

Frank C. Sciurba,

Jessica Bon

Publication year - 2022

Publication title -

chronic obstructive pulmonary diseases journal of the copd foundation

Language(s) - English

Resource type - Journals

ISSN - 2372-952X

DOI - 10.15326/jcopdf.2022.0290

Subject(s) - copd , respiratory tract , pulmonary disease , pathogenesis , respiratory system , medicine , lung , cigarette smoke , pulmonary function testing , disease , obstructive lung disease , immunology , environmental health

Factors beyond cigarette smoke likely contribute to chronic obstructive pulmonary disease (COPD) pathogenesis. Prior studies demonstrate fungal colonization of the respiratory tract and increased epithelial barrier permeability in COPD. We sought to determine whether 1,3-beta-d-glucan (BDG), a polysaccharide component of the fungal cell wall, is detectable in the plasma of individuals with COPD and associates with clinical outcomes and matrix degradation proteins.

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