Open AccessEffects of colchicine on the ovine corpus luteum: role of microtubules in the secretion of progesterone
Author(s) -
R. T. Gemmell,
B. D. Stacy
Publication year - 1977
Publication title -
reproduction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.208
H-Index - 136
eISSN - 1741-7899
pISSN - 1470-1626
DOI - 10.1530/jrf.0.0490115
Subject(s) - corpus luteum , colchicine , luteal phase , secretion , estrous cycle , microtubule , endocrinology , medicine , ultrastructure , chemistry , intracellular , biology , andrology , hormone , microbiology and biotechnology , anatomy
By 4 h after i.v. injection of ewes at the mid-luteal phase of the oestrous cycle with colchicine (1 mg/kg), the concentration of progesterone in peripheral plasma was halved while the content of progesterone in luteal tissue was doubled. The ultrastructure of the luteal tissue showed some specific drug-induced changes: microtubules were no longer present and the intracellular transport and secretion of granules associated with progesterone secretion appeared to be inhibited.