INTRA-UTERINE DEVICE AND EMBRYONIC SURVIVAL IN THE RAT | Zendy

Kenneth Frank DeBoer | Zendy; L. L. Anderson | Zendy; R. M. Melampy | Zendy

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INTRA-UTERINE DEVICE AND EMBRYONIC SURVIVAL IN THE RAT

Author(s) -

Kenneth Frank DeBoer,

L. L. Anderson,

R. M. Melampy

Publication year - 1970

Publication title -

reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.208

H-Index - 136

eISSN - 1741-7899

pISSN - 1470-1626

DOI - 10.1530/jrf.0.0210343

Subject(s) - embryonic stem cell , uterine horns , embryogenesis , andrology , embryo , french horn , survival rate , biology , medicine , anatomy , endocrinology , uterus , microbiology and biotechnology , gene , psychology , pedagogy , biochemistry

The IUD and embryonic survival in the rat were studied by investigating the effect of uterine secretions on ovarian function and embryonic survival. Silk threads were inserted into the right horn of 8 rats. 7 rats were sham operated and 13 rats served as unoperated controls. 1 week after surgery rats were mated and on Day 13 of pregnancy they were killed. There were no embroys in the IUD horns at autopsy and a significant reduction of embryos were present in the opposite horns (.7; p less than .01) compared with the controls (6.6). The embryonic survival rate in sham-operated rats was reduced (p less than.05) as compared with the controls. To determine if the IUD horn contained a substance which reduced embryonic survival it was flushed and the fluid collected was injected into the opposite horn on Day 3 or 4. The fluid caused an additional detrimental effect upon embryonic survival suggesting that the fluid contained antifertility activity (23% embryonic survival) as compared with the fluid from horns not having an IUD (41% embryonic survival).

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