Open AccessMALE ANTIFERTILITY COMPOUNDS: STRUCTURE AND ACTIVITY RELATIONSHIPS OF U-5897, U-15,646 AND RELATED SUBSTANCES
Author(s) -
Ronald J. Ericsson,
Gilbert A. Youngdale
Publication year - 1970
Publication title -
reproduction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.208
H-Index - 136
eISSN - 1741-7899
pISSN - 1470-1626
DOI - 10.1530/jrf.0.0210263
Subject(s) - sterility , biology , physiology , botany
Summary. U-5897 (3-chloro-1,2-propanediol), U-15,646 (1,1\m='\-(penta- methylenedioxy) bis (3-chloro-2-propanol)), and some related com- pounds were found to have antifertility activity in the male rat. Oral administration for 8 days produced temporary sterility of a functional type in the male. Structural characteristics for activity were studied.
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