Selenium and goiter prevalence in borderline iodine sufficiency | Zendy

Volker F. H. Brauer | Zendy; Ulrich Schweizer | Zendy; Josef Köhrle | Zendy; Ralf Paschke | Zendy

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Selenium and goiter prevalence in borderline iodine sufficiency

Author(s) -

Volker F. H. Brauer,

Ulrich Schweizer,

Josef Köhrle,

Ralf Paschke

Publication year - 2006

Publication title -

european journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 148

eISSN - 1479-683X

pISSN - 0804-4643

DOI - 10.1530/eje.1.02302

Subject(s) - goiter , medicine , endocrinology , iodine deficiency , thyroid peroxidase , thyroid , iodine , excretion , creatinine , population , thyroid function , physiology , chemistry , environmental health , organic chemistry

Selenium (Se) is required for the biosynthesis of selenocysteine-containing proteins. Several selenoenzymes, e.g. glutathione peroxidases and thioredoxin reductases, are expressed in the thyroid. Selenoenzymes of the deiodinase family regulate the levels of thyroid hormones. For clinical investigators, it is difficult to determine the role of Se in the etiology of (nodular-)goiter, because there are considerable variations of Se concentrations in different populations as reflected by dietary habits, bioavailability of Se compounds, and racial differences. Moreover, most previous clinical trials which investigated the influence of Se on thyroid volume harbored a bias due to the coexistence of severe iodine deficiency in the study populations.

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