RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture | Zendy

Massimo Santoro | Zendy; Rosa Marina Melillo | Zendy; Alfredo Fusco | Zendy

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RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture

Author(s) -

Massimo Santoro,

Rosa Marina Melillo,

Alfredo Fusco

Publication year - 2006

Publication title -

european journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 148

eISSN - 1479-683X

pISSN - 0804-4643

DOI - 10.1530/eje.1.02289

Subject(s) - thyroid carcinoma , cancer research , endocrinology , medicine , signal transduction , thyroid , biology , microbiology and biotechnology

Papillary thyroid carcinoma (PTC) is frequently associated with RET gene rearrangements that generate the so-called RET/PTC oncogenes. In this review, we examine the data about the mechanisms of thyroid cell transformation, activation of downstream signal transduction pathways and modulation of gene expression induced by RET/PTC. These findings have advanced our understanding of the processes underlying PTC formation and provide the basis for novel therapeutic approaches to this disease.

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