Open AccessLeptin, free leptin index, insulin resistance and liver fibrosis in children with non-alcoholic fatty liver disease
Author(s) -
Valério Nobili,
Melania Manco,
Paolo Ciampalini,
Vincenzo Di Ciommo,
Rita De Vito,
Fiorella Piemonte,
Donatella Comparcola,
Roberto Guidi,
Matilde Marcellini
Publication year - 2006
Publication title -
european journal of endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.897
H-Index - 148
eISSN - 1479-683X
pISSN - 0804-4643
DOI - 10.1530/eje.1.02288
Subject(s) - medicine , leptin , insulin resistance , endocrinology , steatosis , fatty liver , steatohepatitis , liver biopsy , gastroenterology , cirrhosis , homeostatic model assessment , body mass index , insulin , biopsy , obesity , disease
Prevalence of non-alcoholic fatty liver disease (NAFLD) among children is increasing dramatically. It is unclear why some patients develop steatohepatitis (NASH), fibrosis and cirrhosis from steatosis, and others do not. A role for leptin has been claimed. This study aims to evaluate the relationship between leptin, insulin resistance (IR) and NAFLD in children.
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