IGF-I gene promoter polymorphism is a predictor of survival after myocardial infarction in patients with type 2 diabetes
Author(s) -
Mojgan Yazdanpanah,
Fakhredin A. SayedTabatabaei,
J. A. M. J. L. Janssen,
Ingrid Rietveld,
Albert Hofman,
Theo Stijnen,
Huibert A. P. Pols,
Steven W. J. Lamberts,
Jacqueline C.M. Witteman,
Cornelia M. van Duijn
Publication year - 2006
Publication title -
european journal of endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.897
H-Index - 148
eISSN - 1479-683X
pISSN - 0804-4643
DOI - 10.1530/eje.1.02276
Subject(s) - hazard ratio , medicine , type 2 diabetes , myocardial infarction , genotype , rotterdam study , diabetes mellitus , confidence interval , population , proportional hazards model , prospective cohort study , allele , polymorphism (computer science) , endocrinology , gastroenterology , biology , genetics , gene , environmental health
Previously we observed that non-carriers of the most common alleles of an IGF-I promoter polymorphism have low circulating IGF-I levels and an increased risk of developing myocardial infarction (MI), particularly in patients with type 2 diabetes.
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