Hypothalamic–pituitary–gonadal axis in two men with aromatase deficiency: evidence that circulating estrogens are required at the hypothalamic level for the integrity of gonadotropin negative feedback | Zendy

Vincenzo Rochira | Zendy; Lucia Zirilli | Zendy; Alessandro D. Genazzani | Zendy; Balestrieri Antonio | Zendy; Claudio Aranda | Zendy; Bibiana Fabre | Zendy; Paula Antunez | Zendy; Chiara Diazzi | Zendy; Cesare Carani | Zendy; Laura Maffei | Zendy

Open Access

Hypothalamic–pituitary–gonadal axis in two men with aromatase deficiency: evidence that circulating estrogens are required at the hypothalamic level for the integrity of gonadotropin negative feedback

Author(s) -

Vincenzo Rochira,

Lucia Zirilli,

Alessandro D. Genazzani,

Balestrieri Antonio,

Claudio Aranda,

Bibiana Fabre,

Paula Antunez,

Chiara Diazzi,

Cesare Carani,

Laura Maffei

Publication year - 2006

Publication title -

european journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 148

eISSN - 1479-683X

pISSN - 0804-4643

DOI - 10.1530/eje.1.02254

Subject(s) - medicine , endocrinology , aromatase , hypothalamic–pituitary–gonadal axis , gonadotropin , estrogen , hypothalamus , hormone , luteinizing hormone , cancer , breast cancer

In men, the feedback of gonadotropins is regulated by estrogens that come from the aromatization of testosterone, but the relative contribution to the inhibition of LH and FSH secretion by the amount of locally produced estrogens within the hypothalamus and/or the pituitary, and the amount of circulating estrogens still remains unknown.

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