Similar prevalence of somatic TSH receptor and Gsα mutations in toxic thyroid nodules in geographical regions with different iodine supply in Turkey | Zendy

Hülya Ilıksu Gözü | Zendy; Rıfat Bircan | Zendy; Knut Krohn | Zendy; Sandra Müller | Zendy; Selahattin Vural | Zendy; Cem Gezen | Zendy; Haluk Sargın | Zendy; Dilek Yavuzer | Zendy; Mehmet Sargın | Zendy; Beyazıt Çirakoğlu | Zendy; Ralf Paschke | Zendy

Open Access

Similar prevalence of somatic TSH receptor and Gsα mutations in toxic thyroid nodules in geographical regions with different iodine supply in Turkey

Author(s) -

Hülya Ilıksu Gözü,

Rıfat Bircan,

Knut Krohn,

Sandra Müller,

Selahattin Vural,

Cem Gezen,

Haluk Sargın,

Dilek Yavuzer,

Mehmet Sargın,

Beyazıt Çirakoğlu,

Ralf Paschke

Publication year - 2006

Publication title -

european journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 148

eISSN - 1479-683X

pISSN - 0804-4643

DOI - 10.1530/eje.1.02253

Subject(s) - somatic cell , mutation , germline mutation , thyroid , thyrotropin receptor , medicine , population , endocrinology , iodine , biology , genetics , gene , graves' disease , chemistry , environmental health , organic chemistry

Differences in iodine intake could account for the variable prevalences reported for somatic TSH receptor (TSHR) mutations in toxic thyroid nodules (TTNs). However, this question has not been settled, since no study has yet determined the TSHR mutation prevalence in regions with different iodine supplies in the same population using the same methodology. Therefore, we studied the prevalence of somatic TSHR mutations in TTNs from patients living in iodine-deficient or -sufficient regions in Turkey.

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