The effects of tumour necrosis factor-α and interleukin1 on an in vitro model of thyroid-associated ophthalmopathy; contrasting effects on adipogenesis | Zendy

Tom Cawood | Zendy; Paul Moriarty | Zendy; Cliona OʼFarrelly | Zendy; Donal O’Shea | Zendy

Open Access

The effects of tumour necrosis factor-α and interleukin1 on an in vitro model of thyroid-associated ophthalmopathy; contrasting effects on adipogenesis

Author(s) -

Tom Cawood,

Paul Moriarty,

Cliona OʼFarrelly,

Donal O’Shea

Publication year - 2006

Publication title -

european journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 148

eISSN - 1479-683X

pISSN - 0804-4643

DOI - 10.1530/eje.1.02242

Subject(s) - adipogenesis , cytokine , endocrinology , tumor necrosis factor alpha , medicine , hyaluronic acid , glycosaminoglycan , in vitro , graves' ophthalmopathy , chemistry , adipose tissue , thyroid , biochemistry , graves' disease , anatomy

Cytokines are likely to play a key pathogenic role in thyroid-associated ophthalmopathy (TAO). Anti-cytokine therapy has been proposed to be a possible treatment for active TAO. We aimed to establish the effects of selected cytokines on intercellular adhesion molecule 1 (ICAM1) expression, glycosaminoglycan (GAG) production and adipogenesis in orbital fibroblasts (OFs) from patients with TAO.

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