Open AccessBlockade of oestrogen biosynthesis in peripubertal boys: effects on lipid metabolism, insulin sensitivity, and body composition
Author(s) -
Matti Hero,
Carina AnkarbergLindgren,
MarjaRiitta Taskinen,
Leo Dunkel
Publication year - 2006
Publication title -
european journal of endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.897
H-Index - 148
eISSN - 1479-683X
pISSN - 0804-4643
DOI - 10.1530/eje.1.02226
Subject(s) - medicine , endocrinology , adiponectin , aromatase , insulin resistance , letrozole , insulin , aromatase inhibitor , estrogen , testosterone (patch) , cancer , breast cancer
In males, the pubertal increase in sex hormone production has been associated with proatherogenic changes in lipid and carbohydrate metabolism. Aromatase inhibitors, a novel treatment modality for some growth disorders, may significantly influence these risk factors for cardiovascular disease by suppressing oestrogen biosynthesis and stimulating gonadal androgen production. In the current study, we explored the effects of aromatase inhibition on lipid metabolism, insulin sensitivity, body composition and serum adiponectin in peripubertal boys.
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