The ACAA-insertion/deletion polymorphism at the 3′ UTR of the IGF-II receptor gene is associated with type 2 diabetes and surrogate markers of insulin resistance | Zendy

Gemma Villuendas | Zendy; José I. BotellaCarretero | Zendy; Abel LópezBermejo | Zendy; Carme Gubern | Zendy; Wifredo Ricart | Zendy; José Manuel FernándezReal | Zendy; José L. San Millán | Zendy; Héctor F. EscobarMorreale | Zendy

Open Access

The ACAA-insertion/deletion polymorphism at the 3′ UTR of the IGF-II receptor gene is associated with type 2 diabetes and surrogate markers of insulin resistance

Author(s) -

Gemma Villuendas,

José I. BotellaCarretero,

Abel LópezBermejo,

Carme Gubern,

Wifredo Ricart,

José Manuel FernándezReal,

José L. San Millán,

Héctor F. EscobarMorreale

Publication year - 2006

Publication title -

european journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 148

eISSN - 1479-683X

pISSN - 0804-4643

DOI - 10.1530/eje.1.02217

Subject(s) - insulin resistance , type 2 diabetes , medicine , endocrinology , allele , biology , diabetes mellitus , odds ratio , genotype , polymorphism (computer science) , insulin , genetics , gene

The IGF-II receptor gene (IGFIIR) is located at chromosome 6q26, a region that harbors a genetic marker linked to insulin-resistant traits in Mexican-Americans. In the present study conducted in Spaniards, we tested a common polymorphism in IGFIIR for association with type 2 diabetes and insulin-resistant traits.

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