Glycosaminoglycans increase levels of free and bioactive IGF-I in vitro | Zendy

Anne Vestergård Møller | Zendy; Søren Peter Jørgensen | Zendy; Jianwen Chen | Zendy; Anni Larnkjær | Zendy; Thomas Ledet | Zendy; Allan Flyvbjerg | Zendy; Jan Frystyk | Zendy

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Glycosaminoglycans increase levels of free and bioactive IGF-I in vitro

Author(s) -

Anne Vestergård Møller,

Søren Peter Jørgensen,

Jianwen Chen,

Anni Larnkjær,

Thomas Ledet,

Allan Flyvbjerg,

Jan Frystyk

Publication year - 2006

Publication title -

european journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 148

eISSN - 1479-683X

pISSN - 0804-4643

DOI - 10.1530/eje.1.02203

Subject(s) - glycosaminoglycan , heparin , dermatan sulfate , protamine sulfate , endocrinology , medicine , heparan sulfate , in vitro , chemistry , bioavailability , anticoagulant , in vivo , biochemistry , pharmacology , protamine , biology , microbiology and biotechnology

It is unclear how IGFs become separated from their IGF-binding proteins (IGFBPs) in vivo. However, the IGFBPs possess binding sites for glycosaminoglycans (GAGs) and interaction with GAGs alters IGFBP ligand affinity. Accordingly, GAGs may control IGF bioavailability. To test this hypothesis, we investigated the effect of GAGs on serum levels of free and bioactive IGF-I, total IGF-I, and IGFBPs in vitro.

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