A gene-to-gene interaction between aromatase and estrogen receptors influences bone mineral density | Zendy

José A. Riancho | Zendy; Marı́a T. Zarrabeitia | Zendy; Carmen Valero | Zendy; Carolina Sañudo | Zendy; Verónica Mijares | Zendy; Jesús GonzálezMacías | Zendy

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A gene-to-gene interaction between aromatase and estrogen receptors influences bone mineral density

Author(s) -

José A. Riancho,

Marı́a T. Zarrabeitia,

Carmen Valero,

Carolina Sañudo,

Verónica Mijares,

Jesús GonzálezMacías

Publication year - 2006

Publication title -

european journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 148

eISSN - 1479-683X

pISSN - 0804-4643

DOI - 10.1530/eje.1.02189

Subject(s) - aromatase , endocrinology , medicine , bone mineral , estrogen , receptor , estrogen receptor , gene , estrogen receptor alpha , chemistry , osteoporosis , biochemistry , breast cancer , cancer

The aromatization of androgenic precursors is the main source of estrogens in postmenopausal women. We tested the hypothesis that allelic variants of the genes coding for aromatase and estrogen receptors (ER) could interact to determine the estrogenic signals on the bone tissue and, consequently, bone mineral density (BMD).

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