Pediatric renal allograft transplantation does not normalize the increased cortisol/cortisone ratios of chronic renal failure | Zendy

Michael Schroth | Zendy; Christian Plank | Zendy; Manfred Rauh | Zendy; HelmuthGünther Dörr | Zendy; Wolfgang Rascher | Zendy; Jörg Dötsch | Zendy

Open Access

Pediatric renal allograft transplantation does not normalize the increased cortisol/cortisone ratios of chronic renal failure

Author(s) -

Michael Schroth,

Christian Plank,

Manfred Rauh,

HelmuthGünther Dörr,

Wolfgang Rascher,

Jörg Dötsch

Publication year - 2006

Publication title -

european journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 148

eISSN - 1479-683X

pISSN - 0804-4643

DOI - 10.1530/eje.1.02121

Subject(s) - cortisone , medicine , endocrinology , transplantation , chemistry , urine , urinary system

The conversion of cortisol (F) to cortisone (E) is catalyzed by 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2). Children suffering from chronic renal failure (CRF) have a decreased activity of 11beta-HSD2 contributing to increased arterial blood pressure. The objective was to investigate whether a normal conversion of F to E is achieved after renal transplantation (TX) in children.

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