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We aimed to investigate the efficacy of pegvisomant in patients with acromegaly resistant to long-term (&gt; or = 24-month), high-dose treatment with octreotide-LAR (40 mg/month) or lanreotide (120 mg/month).

european journal of endocrinology

Efficacy of 12-month treatment with the GH receptor antagonist pegvisomant in patients with acromegaly resistant to long-term, high-dose somatostatin analog treatment: effect on IGF-I levels, tumor mass, hypertension and glucose tolerance