Leukemia inhibitory factor reduces body fat mass in ovariectomized mice | Zendy

JohnOlov Jansson | Zendy; Sofia MovérareSkrtic | Zendy; Anna Berndtsson | Zendy; Ingrid Wernstedt Asterholm | Zendy; Hans Carlsten | Zendy; Claes Ohlsson | Zendy

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Leukemia inhibitory factor reduces body fat mass in ovariectomized mice

Author(s) -

JohnOlov Jansson,

Sofia MovérareSkrtic,

Anna Berndtsson,

Ingrid Wernstedt Asterholm,

Hans Carlsten,

Claes Ohlsson

Publication year - 2006

Publication title -

european journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 148

eISSN - 1479-683X

pISSN - 0804-4643

DOI - 10.1530/eje.1.02082

Subject(s) - ovariectomized rat , leukemia inhibitory factor , medicine , endocrinology , glycoprotein 130 , leptin , estrogen , cytokine , adipose tissue , chemistry , estrous cycle , bone mineral , obesity , interleukin 6 , osteoporosis

Ovariectomized (OVX) mice are known to gain body fat while exposure to estrogens decreases fat mass. We have previously shown that estrogen replacement therapy enhances the expression of receptors for the cytokine, leukemia inhibitory factor (LIF). LIF and other cytokines acting via the gp130 signal transducing receptor have been reported to decrease obesity. In the present study, we investigated whether LIF treatment can reduce obesity in OVX mice.

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