Detection of BRAF mutation in thyroid papillary carcinomas by mutant allele-specific PCR amplification (MASA) | Zendy

Maria Rosaria Sapio | Zendy; Daniela Posca | Zendy; Giancarlo Troncone | Zendy; Guido Pettinato | Zendy; Lucio Palombini | Zendy; Guido Rossi | Zendy; Gianfranco Fenzi | Zendy; Mario Vitale | Zendy

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Detection of BRAF mutation in thyroid papillary carcinomas by mutant allele-specific PCR amplification (MASA)

Author(s) -

Maria Rosaria Sapio,

Daniela Posca,

Giancarlo Troncone,

Guido Pettinato,

Lucio Palombini,

Guido Rossi,

Gianfranco Fenzi,

Mario Vitale

Publication year - 2006

Publication title -

european journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 148

eISSN - 1479-683X

pISSN - 0804-4643

DOI - 10.1530/eje.1.02072

Subject(s) - thyroid carcinoma , v600e , exon , microbiology and biotechnology , single strand conformation polymorphism , cancer research , point mutation , mutation , biology , thyroid , pathology , gene , medicine , genetics

The somatic point mutation in the BRAF gene, which results in a valine-to-glutamate substitution at residue 600 (BRAF(V600E)), is an ideal hallmark of papillary thyroid carcinoma (PTC). However, its prevalence is varyingly reported in different studies, and its expression in the follicular variant PTC is controversial, reducing its potential usefulness as diagnostic marker.

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