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Lack of association between thyroid autoantibodies and parity in a population study argues against microchimerism as a trigger of thyroid autoimmunity
Author(s) -
Inge Bülow Pedersen,
Peter Laurberg,
Nils Knudsen,
Torben Jørgensen,
Hans Perrild,
Lars Ovesen,
Lone Banke Rasmussen
Publication year - 2005
Publication title -
european journal of endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.897
H-Index - 148
eISSN - 1479-683X
pISSN - 0804-4643
DOI - 10.1530/eje.1.02070
Subject(s) - microchimerism , autoimmunity , autoantibody , thyroid , medicine , endocrinology , population , anti thyroid autoantibodies , parity (physics) , immunology , pregnancy , biology , fetus , antibody , genetics , disease , environmental health , physics , particle physics
Thyroid autoimmunity is more common in females than in males. One possible explanation for this female preponderance may be the effect of oestrogens on the immune system. It has also been suggested that foetal microchimerism involving transfer of foetal cells into maternal tissue during pregnancy may play an important role.

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