Lithium stimulates proliferation in cultured thyrocytes by activating Wnt/β-catenin signalling | Zendy

A S Rao | Zendy; N Kremenevskaja | Zendy; Julia Resch | Zendy; Georg Brabant | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Lithium stimulates proliferation in cultured thyrocytes by activating Wnt/β-catenin signalling

Author(s) -

A S Rao,

N Kremenevskaja,

Julia Resch,

Georg Brabant

Publication year - 2005

Publication title -

european journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 148

eISSN - 1479-683X

pISSN - 0804-4643

DOI - 10.1530/eje.1.02038

Subject(s) - wnt signaling pathway , cyclin d1 , catenin , creb , medicine , endocrinology , chemistry , cell growth , beta catenin , transfection , axin2 , signal transduction , transcription factor , biology , cancer research , microbiology and biotechnology , cell cycle , cell culture , cell , biochemistry , genetics , gene

Lithium, clinically used in the treatment of bipolar disorders, is well known to induce thyroid growth. However, the mechanism involved is only incompletely characterized. Although it is conventionally believed that thyroid proliferation depends on the thyroid-stimulating hormone (TSH)/cAMP/cAMP response element binding protein (CREB) pathway, recent data indicate that Wnt/beta-catenin signalling may be of critical importance. In other cell types lithium activates canonical Wnt signalling by GSK-3beta inhibition, which in turn stabilizes cytosolic free beta-catenin. Here we investigated the potential modulation of Wnt/beta-catenin signalling under lithium treatment in primary and neoplastic human thyrocytes.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research