Sex-specific association of PTPN22 1858T with type 1 diabetes but not with Hashimoto’s thyroiditis or Addison’s disease in the German population | Zendy

Heinrich Kahles | Zendy; Elizabeth RamosLopez | Zendy; Britta Lange | Zendy; O Zwermann | Zendy; Martín Reincke | Zendy; Klaus Badenhoop | Zendy

Open Access

Sex-specific association of PTPN22 1858T with type 1 diabetes but not with Hashimoto’s thyroiditis or Addison’s disease in the German population

Author(s) -

Heinrich Kahles,

Elizabeth RamosLopez,

Britta Lange,

O Zwermann,

Martín Reincke,

Klaus Badenhoop

Publication year - 2005

Publication title -

european journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 148

eISSN - 1479-683X

pISSN - 0804-4643

DOI - 10.1530/eje.1.02035

Subject(s) - ptpn22 , medicine , thyroiditis , endocrinology , odds ratio , type 1 diabetes , addison's disease , allele , genetic predisposition , diabetes mellitus , genotype , disease , single nucleotide polymorphism , biology , genetics , gene

Endocrine autoimmune disorders share genetic susceptibility loci, causing a disordered T-cell activation and homeostasis (HLA class II genes, CTLA-4). Recent studies showed a genetic variation within the PTPN22 gene to be an additional risk factor.

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