The expression of wild-type pendrin (SLC26A4) in human embryonic kidney (HEK 293 Phoenix) cells leads to the activation of cationic currents | Zendy

Silvia Dossena | Zendy; Antonella Maccagni | Zendy; Valeria Vezzoli | Zendy; Claudia Bazzini | Zendy; Maria Lisa Garavaglia | Zendy; G. Meyer | Zendy; Johannes Fürst | Zendy; Markus Ritter | Zendy; Laura Fugazzola | Zendy; Luca Persani | Zendy; Patrick Zorowka | Zendy; Carlo Storelli | Zendy; Paolo BeckPeccoz | Zendy; Guido Fernando Botta | Zendy; Markus Paulmichl | Zendy

Open Access

The expression of wild-type pendrin (SLC26A4) in human embryonic kidney (HEK 293 Phoenix) cells leads to the activation of cationic currents

Author(s) -

Silvia Dossena,

Antonella Maccagni,

Valeria Vezzoli,

Claudia Bazzini,

Maria Lisa Garavaglia,

G. Meyer,

Johannes Fürst,

Markus Ritter,

Laura Fugazzola,

Luca Persani,

Patrick Zorowka,

Carlo Storelli,

Paolo BeckPeccoz,

Guido Fernando Botta,

Markus Paulmichl

Publication year - 2005

Publication title -

european journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 148

eISSN - 1479-683X

pISSN - 0804-4643

DOI - 10.1530/eje.1.02018

Subject(s) - pendrin , hek 293 cells , chemistry , endocrinology , medicine , biophysics , inner ear , chloride channel , reabsorption , microbiology and biotechnology , kidney , biology , biochemistry , anatomy , receptor , gene , transporter

The SLC26A4 protein (pendrin) seems to be involved in the exchange of chloride with other anions, therefore being responsible for iodide organification in the thyroid gland and the conditioning of the endolymphatic fluid in the inner ear. Malfunction of SLC26A4 leads to Pendred syndrome, characterized by mild thyroid dysfunction often associated with goiter and/or prelingual deafness. The precise function of the SLC26A4 protein, however, is still elusive. An open question is still whether the SLC26A4-induced ion exchange mechanism is electrogenic or electroneutral. Recently, it has been shown that human pendrin expressed in monkey cells leads to chloride currents.

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