The tumour necrosis factor (TNF)-α system is activated in accordance with pulse pressure in normotensive subjects with type 1 diabetes mellitus
Author(s) -
José-Miguel González-Clemente,
Gabriel GiménezPérez,
Cristóbal Richart,
Montserrat Broch,
Assumpta Caixàs,
Ana Megía,
Olga GiménezPalop,
I Simón,
Dı́dac Mauricio,
Joan Vendrell
Publication year - 2005
Publication title -
european journal of endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.897
H-Index - 148
eISSN - 1479-683X
pISSN - 0804-4643
DOI - 10.1530/eje.1.02016
Subject(s) - medicine , endocrinology , blood pressure , adiponectin , body mass index , diabetes mellitus , pulse pressure , population , type 2 diabetes , leptin , type 2 diabetes mellitus , insulin resistance , obesity , environmental health
Pulse pressure (PP) and inflammation are important predictors of cardiovascular disease (CVD), even in the normotensive. The age-related increase in PP can be diagnosed up to 20 years earlier in subjects with type 1 diabetes mellitus (T1DM) than in the general population. Some evidence suggests that PP can stimulate inflammation. Our aim was to study the relationship between PP and plasma inflammatory proteins in normotensive subjects with T1DM.
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