Expression of somatostatin receptor subtypes 1–5 in pancreatic islets of normoglycaemic and diabetic NOD mice | Zendy

Eva Ludvigsen | Zendy; Mats Stridsberg | Zendy; Eva Tiensuu Janson | Zendy; S. Sandler | Zendy

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Expression of somatostatin receptor subtypes 1–5 in pancreatic islets of normoglycaemic and diabetic NOD mice

Author(s) -

Eva Ludvigsen,

Mats Stridsberg,

Eva Tiensuu Janson,

S. Sandler

Publication year - 2005

Publication title -

european journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 148

eISSN - 1479-683X

pISSN - 0804-4643

DOI - 10.1530/eje.1.01986

Subject(s) - insulitis , endocrinology , medicine , nod mice , nod , pancreatic islets , islet , biology , diabetes mellitus , somatostatin , receptor

Somatostatin acts on five specific receptors (sst1-5) to elicit different biological functions. The non-obese diabetic (NOD) mouse is an experimental model of type 1 diabetes. The aim of this study was to investigate whether the islet expression of sst1-5 is affected during the development of diabetes in NOD mice, with insulitis accompanied by spontaneous hyperglycaemia.

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