Endoplasmic reticulum stress induces Wfs1 gene expression in pancreatic β-cells via transcriptional activation | Zendy

Kohei Ueda | Zendy; June Kawano | Zendy; Komei Takeda | Zendy; Toshiaki Yujiri | Zendy; Katsuya Tanabe | Zendy; Takatoshi Anno | Zendy; Masaru Akiyama | Zendy; Junichi Nozaki | Zendy; Takeo Yoshinaga | Zendy; Akio Koizumi | Zendy; Koh Shinoda | Zendy; Yoshitomo Oka | Zendy; Yukio Tanizawa | Zendy

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Endoplasmic reticulum stress induces Wfs1 gene expression in pancreatic β-cells via transcriptional activation

Author(s) -

Kohei Ueda,

June Kawano,

Komei Takeda,

Toshiaki Yujiri,

Katsuya Tanabe,

Takatoshi Anno,

Masaru Akiyama,

Junichi Nozaki,

Takeo Yoshinaga,

Akio Koizumi,

Koh Shinoda,

Yoshitomo Oka,

Yukio Tanizawa

Publication year - 2005

Publication title -

european journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 148

eISSN - 1479-683X

pISSN - 0804-4643

DOI - 10.1530/eje.1.01945

Subject(s) - endoplasmic reticulum , medicine , endocrinology , gene expression , gene , unfolded protein response , microbiology and biotechnology , chemistry , biology , genetics

The WFS1 gene encodes an endoplasmic reticulum (ER) membrane-embedded protein. Homozygous WFS1 gene mutations cause Wolfram syndrome, characterized by insulin-deficient diabetes mellitus and optic atropy. Pancreatic beta-cells are selectively lost from the patient's islets. ER localization suggests that WFS1 protein has physiological functions in membrane trafficking, secretion, processing and/or regulation of ER calcium homeostasis. Disturbances or overloading of these functions induces ER stress responses, including apoptosis. We speculated that WFS1 protein might be involved in these ER stress responses.

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