CXCR6 within T-helper (Th) and T-cytotoxic (Tc) type 1 lymphocytes in Graves’ disease (GD) | Zendy

Gabriela Aust | Zendy; Manja Kamprad | Zendy; P. Lamesch | Zendy; E Schmücking | Zendy

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CXCR6 within T-helper (Th) and T-cytotoxic (Tc) type 1 lymphocytes in Graves’ disease (GD)

Author(s) -

Gabriela Aust,

Manja Kamprad,

P. Lamesch,

E Schmücking

Publication year - 2005

Publication title -

european journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 148

eISSN - 1479-683X

pISSN - 0804-4643

DOI - 10.1530/eje.1.01892

Subject(s) - granzyme b , cytotoxic t cell , medicine , cd8 , endocrinology , thyroid , immune system , immunology , biology , biochemistry , in vitro

In Graves' disease (GD), stimulating anti-TSH receptor antibodies are responsible for hyperthyroidism. T-helper 2 (Th2) cells were expected to be involved in the underlying immune mechanism, although this is still controversial. The aim of this study was to examine the expression of CXCR6, a chemokine receptor that marks functionally specialized T-cells within the Th1 and T-cytotoxic 1 (Tc1) cell pool, to gain new insights into the running immune processes.

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