Forskolin and dexamethasone synergistically induce aromatase (CYP19) expression in the human osteoblastic cell line SV-HFO | Zendy

Masatada Watanabe | Zendy; Shuji Ohno | Zendy; Shizuo Nakajin | Zendy

Open Access

Forskolin and dexamethasone synergistically induce aromatase (CYP19) expression in the human osteoblastic cell line SV-HFO

Author(s) -

Masatada Watanabe,

Shuji Ohno,

Shizuo Nakajin

Publication year - 2005

Publication title -

european journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 148

eISSN - 1479-683X

pISSN - 0804-4643

DOI - 10.1530/eje.1.01882

Subject(s) - forskolin , aromatase , medicine , endocrinology , estrogen , oncostatin m , biology , transfection , cell culture , osteoblast , frequency shift keying , gene expression , chemistry , cytokine , gene , interleukin 6 , biochemistry , stimulation , in vitro , channel (broadcasting) , cancer , breast cancer , electrical engineering , demodulation , genetics , engineering

Recent progress supports the importance of local estrogen secretion in human bone tissues to increase and maintain bone mineral density. In a previous study, we reported that the expression of aromatase (CYP19) is dexamethasone (Dex)-dependent and oncostatin M (OSM) increases the expression synergistically with Dex. In the present study, we examined the effects of forskolin (FSK) as another potential synergistic factor.

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