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Pharmacological doses of estrogens or testosterone are used to limit the final height of girls or boys with constitutional tall stature but the mechanism behind this growth inhibition is still debated. We therefore studied the changes in the circulating components of the insulin-like growth factor (IGF) system during high dose sex steroid therapy.

Ethinylestradiol and testosterone have divergent effects on circulating IGF system components in adolescents with constitutional tall stature