C-peptide increases the expression of vasopressin-activated calcium-mobilizing receptor gene through a G protein-dependent pathway | Zendy

Anna Maestroni | Zendy; Dora Ruggieri | Zendy; Giacomo Dell’Antonio | Zendy; Livio Luzi | Zendy; Gianpaolo Zerbini | Zendy

Open Access

C-peptide increases the expression of vasopressin-activated calcium-mobilizing receptor gene through a G protein-dependent pathway

Author(s) -

Anna Maestroni,

Dora Ruggieri,

Giacomo Dell’Antonio,

Livio Luzi,

Gianpaolo Zerbini

Publication year - 2005

Publication title -

european journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 148

eISSN - 1479-683X

pISSN - 0804-4643

DOI - 10.1530/eje.1.01823

Subject(s) - pertussis toxin , peptide , medicine , endocrinology , receptor , vasopressin , chemistry , calcium in biology , ly294002 , intracellular , biology , signal transduction , g protein , phosphatidylinositol , biochemistry

Although an increasing number of reports suggest that physiological concentrations of C-peptide protect against the development of diabetic nephropathy, possibly through the modulation of Na-K pump activity, the intracellular pathways controlled by C-peptide are still unrecognized. C-peptide and vasopressin share similar intracellular effects including the activation of calcium influx and endothelial nitric oxide synthase. Both hormones stimulate also the activity of Na-K pump activity. Whether the activity of C-peptide is mediated by the recently identified vasopressin-activated calcium-mobilizing receptor (VACM-1) has never been previously investigated.

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