Genetic defects in GH synthesis and secretion | Zendy

Gianni Bona | Zendy; R. Paracchini | Zendy; Mara Giordano | Zendy; Patricia MomiglianoRichiardi | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Genetic defects in GH synthesis and secretion

Author(s) -

Gianni Bona,

R. Paracchini,

Mara Giordano,

Patricia MomiglianoRichiardi

Publication year - 2004

Publication title -

european journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 148

eISSN - 1479-683X

pISSN - 0804-4643

DOI - 10.1530/eje.0.151s003

Subject(s) - ighd , endocrinology , medicine , hormone , somatostatin , short stature , secretion , anterior pituitary , biology , somatotropic cell , growth hormone , growth hormone deficiency

Growth hormone (GH) is a multifunctional hormone produced in the anterior pituitary that promotes postnatal growth of skeletal and soft tissues. GH secretion and release are complex phenomena depending on several intrinsic and extrinsic factors modulating the release of two hypothalamic hormones, GH releasing hormone and somatostatin. Any genetic or acquired disorder that impairs GH secretion or action causes a pathological phenotype characterized by harmonic short stature with isolated GH deficiency (IGHD) or combined pituitary hormone deficiency (CPHD). In this article we report current knowledge about the genetic basis of IGHD and CPHD.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research