Open AccessQuantitave and qualitative changes in vascular endothelial growth factor gene expression in glomeruli of patients with type 2 diabetes
Author(s) -
Elena Bortoloso,
Dorella Del Prete,
Michele Dalla Vestra,
Giovanni Gambaro,
Alois Saller,
Francesco Antonucci,
B. Baggio,
Franca Anglani,
Paola Fioretto
Publication year - 2004
Publication title -
european journal of endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.897
H-Index - 148
eISSN - 1479-683X
pISSN - 0804-4643
DOI - 10.1530/eje.0.1500799
Subject(s) - medicine , endocrinology , vascular endothelial growth factor , diabetic nephropathy , messenger rna , pathogenesis , diabetes mellitus , receptor , nephropathy , biology , vegf receptors , gene , biochemistry
Vascular endothelial growth factor (VEGF) exists in three main splice variants, characterized by 121, 165 and 189 amino acids (VEGF 121, VEGF 165 and VEGF 189) and acts via two specific receptors: VEGF-R1 or Flt-1 and VEGF-R2 or KDR. VEGF plays an important role in the pathogenesis of diabetic retinopathy. This study examined the relationship between VEGF and its isoforms and the severity of diabetic nephropathy in type 2 diabetes.
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