A common polymorphism in the 5'-untranslated region of the aromatase gene influences bone mass and fracture risk | Zendy

Marı́a T. Zarrabeitia | Zendy; José L. Hernández | Zendy; Carmen Valero | Zendy; AL Zarrabeitia | Zendy; María Teresa GarcíaUnzueta | Zendy; Amado Ja | Zendy; Jesús GonzálezMacías | Zendy; JA Riancho | Zendy

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A common polymorphism in the 5'-untranslated region of the aromatase gene influences bone mass and fracture risk

Author(s) -

Marı́a T. Zarrabeitia,

José L. Hernández,

Carmen Valero,

AL Zarrabeitia,

María Teresa GarcíaUnzueta,

Amado Ja,

Jesús GonzálezMacías,

JA Riancho

Publication year - 2004

Publication title -

european journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 148

eISSN - 1479-683X

pISSN - 0804-4643

DOI - 10.1530/eje.0.1500699

Subject(s) - medicine , aromatase , endocrinology , polymorphism (computer science) , gene , bone mass , three prime untranslated region , untranslated region , genetics , biology , osteoporosis , genotype , messenger rna , cancer , breast cancer

The aromatization of androgenic precursors in peripheral tissues, including bone, is the main source of estrogens after the menopause. CYP19, the gene encoding aromatase, has a long 5'-untranslated region with several variants of exon I and specific promoters. The aim of this study was to investigate the possible relationship between a common biallelic (C/G) polymorphism located on exon I.2 and bone mineral density (BMD).

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