Functional in vitro studies on the role and regulation of interleukin-6 in human somatotroph pituitary adenomas | Zendy

J. Thiele | Zendy; P. Lohrer | Zendy; L Schaaf | Zendy; M. Feirer | Zendy; W Stummer | Zendy; Marco Losa | Zendy; M. Lange | Zendy; María A. Tichomirowa | Zendy; Eduardo Arzt | Zendy; GK Stalla | Zendy; Ulrich Renner | Zendy

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Functional in vitro studies on the role and regulation of interleukin-6 in human somatotroph pituitary adenomas

Author(s) -

J. Thiele,

P. Lohrer,

L Schaaf,

M. Feirer,

W Stummer,

Marco Losa,

M. Lange,

María A. Tichomirowa,

Eduardo Arzt,

GK Stalla,

Ulrich Renner

Publication year - 2003

Publication title -

european journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 148

eISSN - 1479-683X

pISSN - 0804-4643

DOI - 10.1530/eje.0.1490455

Subject(s) - autocrine signalling , medicine , endocrinology , somatotropic cell , paracrine signalling , pituitary adenoma , acromegaly , biology , adenoma , cytokine , growth factor , pituitary gland , cancer research , hormone , receptor , growth hormone

Interleukin-6 (IL-6), a member of the gp130 cytokine family, is considered to be an important modulator of function and growth in endocrine anterior pituitary cells. In pituitary adenomas, where IL-6 is often produced by the tumour cells, it is thought to be involved in pituitary adenoma pathophysiology via autocrine/paracrine mechanisms.

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