Large carboxy-terminal parathyroid hormone (PTH) fragment with a relatively longer half-life than 1-84 PTH is secreted directly from the parathyroid gland in humans | Zendy

Hiroyuki Yamashita | Zendy; Ping Gao | Zendy; Tom Cantor | Zendy; Tetsuhiro Futata | Zendy; Tsukasa Murakami | Zendy; S. Uchino | Zendy; Shin Watanabe | Zendy; Hitoshi Kawamoto | Zendy; Masafumi Fukagawa | Zendy; Shiro Noguchi | Zendy

Open Access

Large carboxy-terminal parathyroid hormone (PTH) fragment with a relatively longer half-life than 1-84 PTH is secreted directly from the parathyroid gland in humans

Author(s) -

Hiroyuki Yamashita,

Ping Gao,

Tom Cantor,

Tetsuhiro Futata,

Tsukasa Murakami,

S. Uchino,

Shin Watanabe,

Hitoshi Kawamoto,

Masafumi Fukagawa,

Shiro Noguchi

Publication year - 2003

Publication title -

european journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 148

eISSN - 1479-683X

pISSN - 0804-4643

DOI - 10.1530/eje.0.1490301

Subject(s) - parathyroid hormone , medicine , endocrinology , immunoradiometric assay , primary hyperparathyroidism , jugular vein , hyperparathyroidism , basal (medicine) , blood sampling , adenoma , parathyroid gland , parathyroid adenoma , radioimmunoassay , calcium , insulin

It was discovered that an immunoreactive large carboxy-terminal parathyroid hormone (PTH) fragment (large C-PTH), likely 7-84 PTH, is present in the circulation. However, very little is known about the production and metabolism of this large C-PTH. Combining a whole molecule PTH (whole PTH) immunoradiometric assay (IRMA) specifically for 1-84 PTH and an intact PTH (iPTH) IRMA for the sum of 1-84 PTH and large C-PTH, we were able to assess the circulating level of this large C-PTH as well as the glandular secretion and metabolism of this large C-PTH in primary hyperparathyroidism (pHPT).

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