Involvement of stress-activated protein kinase/c-Jun N-terminal kinase in endothelin-1-induced heat shock protein 27 in osteoblasts | Zendy

Haruhiko Tokuda | Zendy; Masayuki Niwa | Zendy; Hidenori Ito | Zendy; Yutaka Oiso | Zendy; Kenji Kato | Zendy; Osamu Kozawa | Zendy

Open Access

Involvement of stress-activated protein kinase/c-Jun N-terminal kinase in endothelin-1-induced heat shock protein 27 in osteoblasts

Author(s) -

Haruhiko Tokuda,

Masayuki Niwa,

Hidenori Ito,

Yutaka Oiso,

Kenji Kato,

Osamu Kozawa

Publication year - 2003

Publication title -

european journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 148

eISSN - 1479-683X

pISSN - 0804-4643

DOI - 10.1530/eje.0.1490239

Subject(s) - mitogen activated protein kinase kinase , ask1 , map2k7 , map kinase kinase kinase , hsp27 , p38 mitogen activated protein kinases , microbiology and biotechnology , protein kinase a , cyclin dependent kinase 2 , kinase , protein kinase c , mitogen activated protein kinase , mapk14 , cyclin dependent kinase 9 , chemistry , c jun , protein kinase r , biology , heat shock protein , biochemistry , hsp70 , transcription factor , gene

We have reported that endothelin-1 (ET-1) activates p38 mitogen-activated protein (MAP) kinase through protein kinase C in osteoblast-like MC3T3-E1 cells, and that p38 MAP kinase plays a role in the ET-1-induced heat shock protein 27 (HSP27). Recently, we found that stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) is activated by ET-1 in these cells. In the present study, we have investigated the involvement of SAPK/JNK in ET-1-induced HSP27 in MC3T3-E1 cells.

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