Open AccessDifferential expression of adrenomedullin and resistin in 3T3-L1 adipocytes treated with tumor necrosis factor-alpha
Author(s) -
Y Li,
Kazuhito Totsune,
Kazuhisa Takeda,
Kazumichi Furuyama,
Shigeki Shibahara,
Kazuhiro Takahashi
Publication year - 2003
Publication title -
european journal of endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.897
H-Index - 148
eISSN - 1479-683X
pISSN - 0804-4643
DOI - 10.1530/eje.0.1490231
Subject(s) - endocrinology , medicine , resistin , adipocyte , insulin resistance , adrenomedullin , 3t3 l1 , tumor necrosis factor alpha , adipose tissue , biology , insulin , chemistry , adiponectin , receptor
It has recently been shown that deficiency of adrenomedullin (AM), a potent vasodilator peptide, leads to insulin resistance. We studied expression of AM in NIH 3T3-L1 adipocytes and compared it with expression of resistin, an adipocyte-derived peptide hormone that is proposed to cause insulin resistance. Moreover, we studied the effects of tumor necrosis factor-alpha (TNF-alpha), a known mediator of insulin resistance, on the expression of AM and resistin in 3T3-L1 adipocytes.
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