Open AccessInterferon-gamma down-regulates claudin-1 and impairs the epithelial barrier function in primary cultured human thyrocytes
Author(s) -
Sofia Tedelind,
LE Ericson,
JO KARLSSON,
Mikael Nilsson
Publication year - 2003
Publication title -
european journal of endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.897
H-Index - 148
eISSN - 1479-683X
pISSN - 0804-4643
DOI - 10.1530/eje.0.1490215
Subject(s) - tight junction , occludin , claudin , barrier function , epithelium , endocrinology , medicine , proinflammatory cytokine , chemistry , interferon gamma , microbiology and biotechnology , cytokine , biology , pathology , inflammation
Proinflammatory cytokines are known to affect the follicular epithelium in autoimmune thyroid disease. Here we investigated the effect of interferon-gamma (IFN-gamma) on the barrier function of primary cultured human thyrocytes.
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