Open AccessMagnetic resonance imaging study of pituitary morphology in subjects homozygous and heterozygous for a null mutation of the GHRH receptor gene
Author(s) -
HA Oliveira,
Roberto Salvatori,
MP Krauss,
C. R. Oliveira,
PR Silva,
MH Aguiar-Oliveira
Publication year - 2003
Publication title -
european journal of endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.897
H-Index - 148
eISSN - 1479-683X
pISSN - 0804-4643
DOI - 10.1530/eje.0.1480427
Subject(s) - ighd , medicine , endocrinology , anterior pituitary , pituitary gland , magnetic resonance imaging , somatotropic cell , hypoplasia , biology , growth hormone deficiency , hormone , growth hormone , radiology
Somatotrophs represent the majority of cells in the anterior pituitary, and their numeric reduction can cause anterior pituitary hypoplasia (APH). Small numbers of patients with familial isolated GH deficiency (IGHD) due to bi-allelic mutations in the GHRH receptor (GHRHR) gene (GHRHR) have been reported to have APH. We tested if APH was present in a large cohort of patients homozygous and heterozygous for a GHRHR mutation.
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