Open AccessA yeast-based functional assay for the detection of the mutant androgen receptor in prostate cancer
Author(s) -
Jocelyn Céraline,
Éva Erdmann,
Philippe Erbs,
M Deslandres-Cruchant,
Didier Jacqmin,
Brigitte Duclos,
C Klein-Soyer,
P. Dufour,
Bergerat Jp
Publication year - 2003
Publication title -
european journal of endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.897
H-Index - 148
eISSN - 1479-683X
pISSN - 0804-4643
DOI - 10.1530/eje.0.1480099
Subject(s) - transactivation , androgen receptor , mutant , biology , androgen , complementary dna , prostate cancer , receptor , wild type , reporter gene , microbiology and biotechnology , gene , gene expression , endocrinology , hormone , cancer , biochemistry , genetics
Mutations in the ligand-binding domain of the human androgen receptor (AR) figure among the ways used by prostate adenocarcinoma (PCa) cells to escape androgen dependence. These mutations may broaden the specificity and/or affinity of the AR to other hormones, resulting in inappropriate receptor activation and thus affecting the PCa response to physiological stimuli and hormonal therapies.
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