During a corticotropin-releasing hormone test in healthy subjects, administration of a beta-adrenergic antagonist induced secretion of cortisol and dehydroepiandrosterone sulfate and inhibited secretion of ACTH | Zendy

S Kizildere | Zendy; T. Glück | Zendy; B. Zietz | Zendy; J Schölmerich | Zendy; Rainer H. Straub | Zendy

Open Access

During a corticotropin-releasing hormone test in healthy subjects, administration of a beta-adrenergic antagonist induced secretion of cortisol and dehydroepiandrosterone sulfate and inhibited secretion of ACTH

Author(s) -

S Kizildere,

T. Glück,

B. Zietz,

J Schölmerich,

Rainer H. Straub

Publication year - 2003

Publication title -

european journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 148

eISSN - 1479-683X

pISSN - 0804-4643

DOI - 10.1530/eje.0.1480045

Subject(s) - medicine , endocrinology , dehydroepiandrosterone sulfate , corticotropin releasing hormone , dehydroepiandrosterone , hormone , hydrocortisone , propranolol , androgen

In chronic inflammatory diseases, serum levels of dehydroepiandrosterone (DHEA) sulfate (DHEAS) are low. Interestingly, several non-inflammatory diseases display similarly low levels of DHEAS which points to other inhibitory factors such as an activated sympathetic nervous system (SNS) (e.g. in patients with heart failure, fibromyalgia, or cancer cachexia). We aimed to identify the influence of the SNS tone on stimulated adrenal steroid secretion in 16 male and 12 female healthy subjects.

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