Open AccessReal-time PCR provides evidence for thyrotropin receptor mRNA expression in orbital as well as in extraorbital tissues
Author(s) -
Patrizia Agretti,
Luca Chiovato,
G. De Marco,
Claudio Marcocci,
Barbara Mazzi,
Stefano SellariFranceschini,
Paolo Vitti,
Aldo Pinchera,
Massimo Tonacchera
Publication year - 2002
Publication title -
european journal of endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.897
H-Index - 148
eISSN - 1479-683X
pISSN - 0804-4643
DOI - 10.1530/eje.0.1470733
Subject(s) - thyrotropin receptor , real time polymerase chain reaction , pathogenesis , messenger rna , thyroid , gene , microbiology and biotechnology , taqman , gene expression , biology , receptor , endocrinology , medicine , graves' disease , genetics
The TSH receptor (TSHr) expressed on thyroid follicular cells is the autoantigen involved in the pathogenesis of Graves' hyperthyroidism. Whether this receptor is expressed in extrathyroidal tissues, and whether it participates directly in the pathogenesis of thyroid-associated ophthalmopathy (TAO) is unclear.
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