Central ghrelin production does not substantially contribute to systemic ghrelin concentrations: a study in two subjects with active acromegaly | Zendy

FM van der Toorn | Zendy; J. A. M. J. L. Janssen | Zendy; WW de Herder | Zendy; Fabio Broglio | Zendy; Ezio Ghigo | Zendy; AJ van der Lely | Zendy

Open Access

Central ghrelin production does not substantially contribute to systemic ghrelin concentrations: a study in two subjects with active acromegaly

Author(s) -

FM van der Toorn,

J. A. M. J. L. Janssen,

WW de Herder,

Fabio Broglio,

Ezio Ghigo,

AJ van der Lely

Publication year - 2002

Publication title -

european journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 148

eISSN - 1479-683X

pISSN - 0804-4643

DOI - 10.1530/eje.0.1470195

Subject(s) - ghrelin , medicine , endocrinology , acromegaly , stimulation , hormone , growth hormone

In an animal model of acromegaly (PEPCK-hGH transgenic mice), low systemic levels of ghrelin have been observed compared with normal mice. We hypothesized that systemic circulating ghrelin levels are also decreased in humans with active acromegaly and that the contribution of central ghrelin production to systemic ghrelin levels is minimal.

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