Nateglinide, but not repaglinide, stimulates growth hormone release in rat pituitary cells by inhibition of K channels and stimulation of cyclic AMP-dependent exocytosis | Zendy

Jesper Gromada | Zendy; Krister Bokvist | Zendy; Marianne Høy | Zendy; HL Olsen | Zendy; Per Lindström | Zendy; BS Hansen | Zendy; CF Gotfredsen | Zendy; Patrik Rorsman | Zendy; MK Thomsen | Zendy

Open Access

Nateglinide, but not repaglinide, stimulates growth hormone release in rat pituitary cells by inhibition of K channels and stimulation of cyclic AMP-dependent exocytosis

Author(s) -

Jesper Gromada,

Krister Bokvist,

Marianne Høy,

HL Olsen,

Per Lindström,

BS Hansen,

CF Gotfredsen,

Patrik Rorsman,

MK Thomsen

Publication year - 2002

Publication title -

european journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 148

eISSN - 1479-683X

pISSN - 0804-4643

DOI - 10.1530/eje.0.1470133

Subject(s) - nateglinide , repaglinide , endocrinology , medicine , exocytosis , stimulation , somatotropic cell , chemistry , biology , insulin , secretion , hormone , pituitary gland , metformin , diabetes mellitus , type 2 diabetes

GH causes insulin resistance, impairs glycemic control and increases the risk of vascular diabetic complications. Sulphonylureas stimulate GH secretion and this study was undertaken to investigate the possible stimulatory effect of repaglinide and nateglinide, two novel oral glucose regulators, on critical steps of the stimulus-secretion coupling in single rat somatotrophs.

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