Expression of G(alpha)(s) proteins and TSH receptor signalling in hyperfunctioning thyroid nodules with TSH receptor mutations | Zendy

HP Holzapfel | Zendy; Benjamin Bergner | Zendy; Peter Wonerow | Zendy; Ralf Paschke | Zendy

Open Access

Expression of G(alpha)(s) proteins and TSH receptor signalling in hyperfunctioning thyroid nodules with TSH receptor mutations

Author(s) -

HP Holzapfel,

Benjamin Bergner,

Peter Wonerow,

Ralf Paschke

Publication year - 2002

Publication title -

european journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.897

H-Index - 148

eISSN - 1479-683X

pISSN - 0804-4643

DOI - 10.1530/eje.0.1470109

Subject(s) - endocrinology , medicine , receptor , alpha (finance) , g protein , biology , basal (medicine) , thyrotropin receptor , alpha 2 adrenergic receptor , signal transduction , thyroid , microbiology and biotechnology , graves' disease , construct validity , nursing , insulin , patient satisfaction

Constitutively activating mutations of the thyrotrophin receptor (TSHR) are the main molecular cause of hyperfunctioning thyroid nodules (HTNs). The G protein coupling is an important and critical step in the TSHR signalling which mainly includes G(alpha)(s), G(alpha)(i) and G(alpha)(q)/11 proteins.

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